Introduction

CV247 is a side-effect-free adjuvant treatment regime for improving the well-being and life expectancy of dogs suffering from malignant tumours and for delaying the recurrence of otherwise treated or surgically removed or de-bulked malignant tumours. The treatment is supplied as an oral base solution, to be mixed with powdered ascorbic acid (Vitamin C) before use.

The calculated dose, as determined by your dog’s weight, is administered directly into the mouth with supplied syringe or mixed into a small amount of your dog’s food or drinking water to ensure the dose is completely ingested.  It is best given just before a meal. The dose needs to be given twice daily.

Composition: CV247

The base solution contains three ingredients in distilled water: Sodium Salicylate, Manganese Gluconate and Copper Gluconate. 10ml of this is added 400 mg Ascorbic Acid powder to make up the treatment.

Contra-indications: CV247

CV247 should not be used in animals who are:

- Suffering from gastrointestinal ulceration or bleeding

- Hypersensitive to any component of the formulation

- Pregnant or if lactating

Please note:

- It cannot be given to cats

Mode of action

All 4 ingredients are known to have some antitumour effect acting as antioxidants, immune-stimulants and anti-prostaglandin roborants. Manganese and Copper are essential trace elements needed for the functionning of several enzymes promoting immunity and biochemical functions including the prevention of oxidation. These enzymes are malfuntionning in malignant disease and allow oxidative DNA damage. Vitamin C also acts as an antioxidant eliminating reactive free radicals and stimulating the immune system, which is under undue strain in malignant disease. It also promotes DNA repair.

Sodium salicylate has anti-inflammatory and analgesic effect mainly through the blocking of prostaglandin production resulting in an improvement in well-being. It is also an antioxidant through blocking the cyclooxigenase (COX) enzymes which cause undue oxidation and subsequent DNA damage and vigorous vascularisation of growing tumours. It may also assist in trying to restore the balance between the natural cell-death rate (apoptosis) and the excessive cell reproduction in malignant tumour growth.

While all 4 ingredients were selected for their well known antitumour effects, it became soon apparent in the trials that this combination together with diet changes gave a rapid and noticeable improvement in the well-being of even the most severely affected cancer patients in up to 90 % of cases. Antitumour effects have also been observed (including cases of apparent full remission), but not yet in sufficient numbers for statistical justification of its registration as an antitumour therapy. It is, therefore, registered at present as an adjuvant, immunstimulant, roborant therapy for dogs affected with malignant tumours, with some possible antitumour effect, which will be further studied through feedback data during its clinical use as an adjuvant/roborant for cancer patients.

Recommended optional home-prepared diet

This is an outline of the diet originally devised by veterinary surgeon John Carter to compliment the treatment. The drastic reduction of salt, sugar, fat, colouring, flavouring agents and preservatives, supports the action of CV247. If possible use organic ingredients. However we have devised a modification of this diet based on our own experiences in helping cancer patients.

%	Proportion	Preparation	Type of food	Choices
20	1/5	Raw	Fibrous vegetable	carrot, lettuce, apple, pear, banana etc
20	1/5	Cooked	Fibrous vegetable	cabbages, cauliflower, broccoli etc
20	1/5	Baked	Fibrous vegetable	oat flakes, muesli, brown bread
20	1/5	Cooked	Starchy, vegetable	potatoes, rice, pasta
10	1/10	Cooked	Animal	poultry, veal, rabbit
5	1/20	Slightly cooked	Animal	egg, boneless fish
5	1/20	Slightly cooked	Animal	liver (other than duck or goose)